• 姓       名:冯百岁
  • 职       称:教授
  • 学       位:博士
  • 所在机构:郑州大学 第一附属医院
  • 出生年月: 1965年10月
  • 籍       贯:河南省孟州市
  • 研究方向:炎症性肠病基础于临床;ERCP诊疗技术
个人简介 学术成果 发表论文

教育背景

1983-1988年就读于河南医科大学,获医学学士。

1991-1994年郑州大学攻读硕士研究生(统招),获硕士学位。

2005-2009年郑州大学攻读博士研究生(统招),获博士学位。

工作经历

2006-2007年做为教育部访问学者在加拿大McMaster大学,从事炎症性肠病(IBD)免疫学机制研究,并完成博士论文《肥大细胞在细菌性腹泻中的作用机制研究》。

2016.9-2016.10加拿大McMaster大学高级访问学者。

1994-2016在郑州大学第一附属医院消化内科工作,任主治医师、副主任医师(副教授)、主任医师(教授)。

2016-至今在郑州大学第二附属医院工作,任消化内科主任。

学术兼职

中国医师协会消化医师分会委员

中华消化学会IBD学组委员

吴阶平医学基金会中国IBD联盟常委

北京医学奖励基金会IBD专家委员会常委

中国医疗器械行业协会消化内镜创新发展分会理事

河南省免疫学会黏膜免疫委员会主任委员

河南省消化学会副主任委员

河南省消化内镜学会常委

河南省消化学会IBD学组组长

河南省消化内镜学会ERCP学组副组长

河南省消化学会HP与微生态学组副组长

河南省特聘学科带头人

河南省卫生科技创新型人才

国家自然科学基金面上项目和重大项目同行评议专家

《中华炎症性肠病杂志》、《世界华人消化杂志》、《郑州大学学报(医学版)》等杂志编委及审稿专家

郑州市二七区政协委员、中国致公党党员

科研项目

主持包括国家自然科学基金面上项目、省部共建项目等15项。

论文专著

参编人卫出版社专著2部。

1. Lin-Jing Li, Lu Zeng, Xiao-Xi Li, Li-Hua Mo, Xiao-Rui Geng, Peng-Yuan Zheng,Zhi-Gang Liu, Bai-Sui Feng* & Ping-Chang Yang*.Induction of colitis in mice with food allergen-specific immune response. Sci Rep. 2016;6:32765

2. Lin-Jing Li, Chen Gong, Mei-Hua Zhao and Bai-Sui Feng*.Role of interleukin-22 in inflammatory bowel disease.World Journal of Gastroenterology.2014;20(48): 18177-88

3. Lin-jing Li, Li-hua Mo, Hui-jie Hao, Wan-he Yang, Quan-bo Zhou, Fu-min Xue, Zhao-yang Shi, Zhi-gang Liu, Ping-Chang Yang and Bai-sui Feng*. Flagellin modulates TIM4 expressionin mast cells.Cell Biology International.2014;38(11): 1330-6

4. Liu Z, Feng BS, Yang SB, Chen X, Su J, Yang PC.Interleukin (IL)-23 suppresses IL-10 in the intestine of inflammatory bowel disease. J Biol Chem. 2012;287(5): 3591-7

5. Chen X, Song CH, Feng BS, Li TL, Li P, Zheng PY, Chen XM, Xing Z, Yang PC.Intestinal epithelial cell-derived integrin αβ6 plays an important role in the induction of regulatory T cells and inhibits an antigen-specific Th2 response.JLeukoc Biol. 2011;90(4):751-9

6. Feng BS, Chen X, Li P et al. Expression of integrin alphavbeta6 in the intestinal epithelial cells of patients with inflammatory bowel disease. North American Journal of Medical Sciences. 2009;1(4):200-4

7. Feng BS, Chen X, He SH, et al. Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)–1/TIM4 interaction as a therapeutic strategyin a dendritic cell–induced peanut allergy model.J Allergy ClinImmunol. 2008 ;122(1):55-61

8. Feng BS, Zheng PY, Chen X, et al. Investigation of the role of cholera toxin in assisting the initiation of the antigen-specific Th2 response.Immunol Invest.2008;37(8):782-97

9. Feng BS, Yang PC.Interaction of bacterial antigen and FC gamma receptor on mast cell induces inflammation in the intestine, a novel mechanism of IBD.Gastroenterology(Suppl). 2008;134(4) A156

10. Feng BS, He SH, Zheng PY, et al. Mast Cells Play a Crucial Role in Staphylococcusaureus Peptidoglycan-Induced Diarrhea. The American Journal of Pathology, 2007;171(2):537-47

11. Yang LT, Li XX, Qiu SQ, Zeng L, Li LJ, Feng BS, Zheng PY, Liu ZG, Yang PC.Micro RNA-19a suppresses thrombospondin-1 in CD35+ B cells in the intestine of mice with food allergy.Am J Transl Res. 2016;8(12):5503-5511.

12. Yang G, Zhang H, Liu Y, Feng Y, Luo XQ, Liu ZQ, Geng XR, Wang S, Zheng PY, Feng BS, Liu ZG, Yang PC, Li HB, Wu SD. Alternation of circadian clock modulates fork head box protein-3 gene transcription in CD4+T cells in the intestine.J Allergy Clin Immunol. 2016;138(5):1446-1449

13. Cai M, Zeng L, Li LJ, Mo LH, Xie RD, Feng BS, Zheng PY, Liu ZG, Liu ZJ, Yang PC. Specific immunotherapy ameliorates ulcerative colitis.Allergy Asthma Clin Immunol. 2016: 5;12:37.

14. Lin-Jing Li, Na Ma, Lu Zeng, Li-Hua Mo, Xiao-Xi Li, Ling-Zhi Xu, Bo Yang, Zhi-Gang Liu, Bai-Sui Feng, Peng-Yuan Zheng, Huan-Ping Zhang, Ping-Chang Yang. Flagellin modulates IgE expression in B cells to initiate food allergy in mice. Am J Transl Res 2016;8(6):2748-2757

15. Wu W, Sun M, Zhang HP, Chen T, Wu R, Liu C, Yang G, Geng XR, Feng BS, Liu Z, Liu Z, Yang PC. Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation.Gut. 2014;63:1883-1892

16. Xiao-Rong Xu, Chang-Qin Liu, Bai-Sui Feng, Zhan-Ju Liu. Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease. World J Gastroenterol.2014; 20(12): 3255-3264.

17. Liu X, Feng BS, Kong X, Xu H, Li X, Yang PC, Liu Z.Food-Cooking Processes Modulate Allergenic Properties of Hen's Egg White Proteins. Int Arch Allergy Immunol. 2013 ;160(2):134-142

18. Fu-Min Xue, Huan-Ping Zhang, Hui-Jie Hao, Zhao-Yang Shi, Chuan Zhou, Baisui Feng, Ping-Chang Yang. CD98 Positive Eosinophils Contribute to T Helper1 Pattern Inflammation. PLoS One.2012;7(12): e51830

19. Chen X, Song CH, Liu ZQ, Feng BS, Zheng PY, Li P, In SH, Tang SG, Yang PC. Intestinal epithelial cells express galectin-9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine. Allergy. 2011, 66(8): 1038-46.

20. Liu T, Chen X, Feng BS, He SH et al. Glucuronoxylomannan promotes the generation of antigen-specific T regulatory cell that suppresses the antigen specific Th2 response upon activation. J Cell Mol Med. J Cell Mol Med. 2009 ;13(8B):1765-74

21. Zheng PY, Feng BS, Oluwole C,et al. Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine. Gut. 2009 ;58(11): 1473-9

22. Chen X, Feng BS, Zheng PY et al. Fc gamma receptor signaling in mast cells links microbial stimulation to mucosal immune inflammation in the intestine. The American Journal of Pathology. 2008 173(6) :1647-56

23. Linda Wu, Feng BS, He SH et al. Bacterial peptidoglycan breaks down intestinal tolerance via mast cell activation: The role of TLR2 and NOD2. Immunol Cell Biol. 2007;85(7):538-45

24. Yang PC… Feng BS. TIM-4 expressed by mucosal dendritic cells plays a critical role in food antigen-specific Th2 differentiation and intestinal allergy. Gastroenterology. 2007;133(5):1522-33

奖励/荣誉

肠道免疫应答和微生物调节异常诱导肠黏膜炎症发生机制和临床应用,获教育部科技进步二等奖